Metabolic health
Weight Loss and Muscle: Why Body Composition Matters
Body weight is the most available number in health and the least informative per kilogram: it cannot tell lost fat from lost…
The reading room
Articles
Explore the science, examine the evidence and follow the questions.
Metabolic health
Semaglutide, Tirzepatide and Retatrutide: Similarities, Differences and Evidence
Same hormone family, different receptors, different labels: what semaglutide, tirzepatide and investigational retatrutide share, and what the trials can and cannot prove.
Metabolic health
Retatrutide Trial Results: What the Headlines Leave Out
What follows is a living summary of retatrutide's trial record, not a forecast of approval or availability. Retatrutide (LY3437943) is Eli Lilly's…
Metabolic health
Retatrutide Explained: The Science Behind the Triple Agonist
One molecule, three hormone receptors — and unusually deep published evidence for an unapproved drug. What retatrutide's trials actually measured, what they…
Research literacy
Approved Medicines, Clinical Trials and “Research Use Only”: What Is the Difference?
Regulators approve specific products for specific uses; trials test investigational medicines under supervision; “research use only” labels do none of these jobs.…
Research literacy
What Are Peptides? A Plain-English Guide to the Science
Start with the smallest honest definition. Your body builds proteins from twenty-odd building blocks called amino acids. When amino acids link together…